T O P

Scientist added jellyfish genes to crap fish DNA and these glowing fish are the result

Scientist added jellyfish genes to crap fish DNA and these glowing fish are the result

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AmbitiousAd6354

Why didn’t they use quality fish ?


DeanSmartin

I'm a crap human...I wanna glow!


le_trout

*Professor Farnsworth voice* "Fry, that went out of style 80 years ago when the glowy people got sick of moths constantly flitting around their heads!"


oneyzema

L A M P


AMC_Tendies42069

I think he meant Carp


DeanSmartin

Whaaaaa? And now I've told everyone that I'm a crap human? Fuuuuuuuck me!


AMC_Tendies42069

The good news is you can eat Carp!


MotherBathroom666

You can eat crap as well, just have decent health insurance.


KFrosty3

And if you don't have decent insurance, you can still eat it anyway and die of poo poisoning


pixeldust6

"Here lies DeanSmartin. Died of poo poisoning."


DyleanCuisine

Pooison


kaazuma_

Is poo poisoning counted as food poisoning


OutrageousPudding450

If food is stuff you eat and you eat poo then yes definitely.


Booblicle

The bad news is it still tastes like Crap


Ladygytha

I've been sitting here thinking, "there are no "crap" fish. Each fish has a different place in fish society, damnit!" Then I saw your comment and immediately cooled down. Even if that's not what OP meant, I'm happier for this clarification, so I thank you.


Picard_Indeed

Or crappies.


beluuuuuuga

I would have put myself forwards for the experiment if they had wanted me for I am the pinnacle of crap.


Kretios

You're going places my friend.


AmbitiousAd6354

Can’t wait until Gordon’s glow sticks hit Walmart freezers !!!


AITAModsArePussies

I can't decide if I want to live in a world where fish sticks and glow sticks are the same thing


aFiachra

See, now I want glowing fish sticks. You bastard!


WonTonBurritoMeals

Goldfish are quality fish if you care for them properly. I have 4 fat nuggets and I love them


ABottleInFrontOfMe

I wonder if they meant crappie? But idk. Doesn’t look like crappie. Edit: ahhh yes. Carp. That makes sense. Im an idiot.


CrappyMSPaintPics

They meant carp.


Me_Arse

Crap fish? What next - shit birds?


PsychonauticalEng

You're drunk Mr. Lahey.


Pennzoil

RIP :(


EnjoytheDoom

I got to see him live with Randy in my hometown right before. I didn't know he only smoked weed! (Not that I thought he was drunk he's just like the very best at it.)


PsychonauticalEng

Frick you for reminding me. I'm gonna keep distracting myself with memes so I'm not sad.


ThatSmile

His character felt so alive that I keep forgetting he died.


Zip668

[I am the liquor.](https://youtu.be/zWCBghizQUs?t=17)


deliciousprisms

*Big, dirty shit hawks.* They’re comin, Bubbles.


2_Fives

Jesus Lahey, your drunk again!


Popular_Patience_328

There's a shitnado comin', Randy.


kslater22

God damn shithawks


LCplDayDay

Jim Lahey is a fuckin’ drunk and he always will be.


AMiniMinotaur

“Look Randers! I’m mowing the air!”


Toast_On_The_RUN

You pissed yourself Mr Lahey...


Fleetmaster1

For the people that don’t know. ( I’m assuming that you do) he misspelt Carp. Edit: I ironically misspelt carp while making my correction. Karma is a bitch.


SpiralingStray

Hi, im one of the ppl that didnt know.. thank you!


MagicSwatson

Oh crap, here we go again.


gwaydms

I saw the title, then the video. I thought "Crap? Those are goldfish!.... Which are... *carp.*" Duh.


ConfessSomeMeow

Ah, I thought it might have been an abbreviation for 'crappie', which is a type of fish. Not that I can tell them apart.


Masterhaend

That's just regular birds.


SunshineMoonLit

Birds aren't real though


ipatimo

Inform me please when it will be commercially available together with hypoallergenic cats, of course if I will be still alive then.


looking4mycocksock

So we shouldn’t summon you from the dead when these become available?


LtSoundwave

Summon me too, please.


Lazy_Imagination_656

Ditto


DuskSlayer198

Count me in!


Kryptyx

RemindME! 7365 years "welcome back"


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WatchingDeath

Poor remind me bot, we are all going to be gone SOMEDAY and you’re still going to be sending those messages.. F🥲


Notanidiot67

Remind me bot will be assimilated by the 4 legged walking sniper rifles by next Friday.


sturnus-vulgaris

Remind me bot inhabits the shell of a combat bot. Walks around occasionally pumping a round into random patches of dirt where the hive mind remembers the Remind Me users were placed in mass graves. After shooting the last reminder someone thought would be funny four billion years in the future, the Remind Me shell walks into the sunset and is seen in silhouette. Sol has become a massive red giant, licking at the upper atmosphere, threatening to finally consume the weary remains of Earth. One muffled shot is heard in the distance as the silhouette falls, it's inane mission completed.


MaybeImWrong

There will come soft rains...


FuglyShmugly

shit man when i saw that 9386 year and date it kinda hit me someone would one day have that in their calendar and won't even care, meanwhile all that's left of me is some stuff i said on the internet


FuckYourTheocracy

It's always a good time for an existential crisis!


ChazJ81

Same. But will this stuff even be able to found then?


Big_Cryptographer_16

The Wayback Machine will hold onto anything stupid we ever said I’m sure


RichiZ2

Bruh, you also have to remember that our measure of time is just the latest. For all we know the people before the Egyptians were already passed the 20k mark, but we will never know, as that tech and records of that civilization are long gone. We could perfectly just be the next in line.


Broad-Personality-49

By that time the internet would have evolved through the use of quantum computation and newly discovered properties into a biological hyper intelligence platform that every sapient life form has/are/and always ingest as it becomes a part of their evolutionary being across the galaxy. Maybe. We've come a long way in 100 years, 9386 is a long fckin time.


Picklewitdajuice

Imagine if this one message above lead to the sentience of a bot, determined to finding this user and discovering a way to resurrect them from the grave, all so it could carry out its last remaining command or reminding the user of this post in 7000 years…


spitfiur

Some cats are randomly close to hypoallergenic genetically. You just gotta go around rubbing kittens on your face until you find one you don’t react to i got lucky with mine


insaKnity

Look at certain breeds too! A good chunk of cat allergies are caused by a protein found in saliva, but a bunch of breeds don't produce near as much of that protein as others. Russian blues and Manx cats are two of such breeds. My family ended up getting two manxes and my severely allergic dad can be around then just fine.


TentaclesAndCupcakes

Also Devon Rexes! They have curly fur and throw off less dander.


MountainEmployee

They look like little lions I want one.


TentaclesAndCupcakes

They are VERY naughty! Mine like to climb up onto tall things like the top of doors and jump down and scare you lol.


Bean--Sidhe

Gotta be honest a life of rubbing kittens on your face isn't a bad way to exist.


SqueezeTwiceForNo

It is if you're allergic


DaughterEarth

My poor ex has had multiple people introducing him to hypoallergenic cats. Every single one, same thing, guy turns in to a poofy, leaking tomato with burrs in his throat. Some people really are just THAT allergic.


Purple-Dragoness

Glowing cats and rabbits have been made. But the skin glows and only under a blacklight; not the fur. Also, purina recently came out with the Live Clear diet which is supposed to help make cats less allergenic to owners :)


reddit4485

This is routinely done in mice to label specific cells. It's called green fluorescent protein and the people who pioneered it won the Nobel prize.


illpoopinyourmouth

Only one of the guys who did the work got the nobel


crobsonq2

It was pretty common before CRISPR. It was hard to tell which cells in the dish took the modified DNA, and fluorescence made it easy to separate the modified cells in the sample.


TomTop64

still used a shit ton btw, doesn’t just apply to pre crispr times


colicab

I would like to know more about this magical food that makes cats less deadly to my wife and kids because DAMMIT I want a cat. Edit: just did some research and apparently it’s called LiveClear. I’m gonna try and talk my wife into it. Wish me luck.


takeitallback73

dont bother I've been eating it for a month and still alergic


Purple-Dragoness

Live clear, sorry. Got it mixed up with an acne medication. Try it! Takes 3.weeks of use though to see benefits :S


-Pencilvester-

I have a hypoallergenic cat, two of them actually. Siberian Forest Cats. They're a breed that generally has low levels of FEL D 1, which is commonly what people are allergic to in cats. I have allergies to cats and dogs, but these cats I can be around with no problem. I can lay my face right on my cats fur and I won't have any issues. Find a Siberian Forest Cat breeder near you and ask if they will either mail you some fur taken directly from a cat (often they will charge for this) or ask if you can visit their Cattery to spend some time around a cat or two. Definitely worth looking into if you're seriously wanting a cat but have allergies. I hated cats until we got our poops. [My buddy Beans](https://i.redd.it/ql55428cwsc61.jpg)


K-Martian

[Are we sharing pics of our Siberian cats?!](http://imgur.com/a/H0uMXIZ)


___Ender____

They are both available. The short-haired Devon Rex and Cornish Rex cats are thought to be less allergenic because they have less hair to shed, resulting in fewer saliva-coated particles in the air. Some people with allergies can also tolerate the hairless Sphynx. Scientists created the GloFish by inserting fluorescent genes from jellyfish and sea anemones into the eggs of a silver and black zebra danio, a tropical fish from India. The fish was designed to help scientists determine when waterways were contaminated. If they glowed, it meant there were pollutants in the water. https://www.glofish.com/ They sell glo fish at Walmart dude


Realistic-Account-55

I havent seen a Walmart with a fish section in over a decade...


Zucchinifan

I used to work there in that area and catch the fish for people, ama


HonorableHam

They actually hired a fish guy for yours? My store it was "go get someone from CAP2, they'll do it"


Realistic-Account-55

Did the fish ever die, and if so what was managements policy on employees eating the dead fish while on the clock?


_akrom

We had one loss prevention guy and not enough managers. I didn't care what the policy was, I always left the fish department full.


babybarracudess2

Yes they do but to make them ‘glo’ you need the ‘glo light’ that comes with the ‘glo tank’….Otherwise they are just colorful…


Jayer244

They already are and are marketed under the name [GloFish](https://shop.glofish.com/)


BearTradez

Those are UV they don’t glow.


kevoizjawesome

The ones in the OP don't glow until they get held up to a uv light as well though


streamofbsness

Fluorescence and luminescence are different things. The first changes light of one wavelength to another (e.g. UV -> green). The second actually generates light, which requires the animal to allocate a lot of energy constantly and is more complex. Just put a black light in your fish tank and call it a day.


ConcreteL10n

Just get a Sphynx


TheRedGoatAR15

If I eat one, will it make my crap glow?


the_wacky_introvert

My man asking the important questions!


beluuuuuuga

If I crap luminescent crap can I have glowing poop sword?


_quick_question__

You can have a glowing poop knife if your glow po is too big


WaterGruffalo

Poop knife will live on forever.


EverySingleThread

#


topramenshaman1

The true darksaber


muklan

Hey, I'm here representing everyone ever when I cordially ask you to not.


joeChump

You will blend the DNA from two craps together. This could result in a monstrous outcome and thus we should try it immediately.


[deleted]

Crapmera?


joeChump

Possibly. Or maybe a Crapen. Or a Crap Ness Monster. Or a Sasquat. Or a King Pong. Or a chupacrapbra. Or just crapal tunnel syndrome…


KevlahR

Poopicabra


joeChump

Banshiit. Cycraps. Medeucer.


mindbreak_gone_

Crapthulu


joeChump

Don’t forget a unicornhole


OffrButtBaby

Bono


AITAModsArePussies

2 cups, 1 girl: a reboot


The_circumstance

The BFP will probably be disintegrad by your stomach. But maybe if you eat really many of them you could marvel at your slightly blue poo.


TylerLikesDonuts

When I was deployed in Guam there was this ice cream joint next to a Burger King downtown. I got this Cookie Monster ice cream which’s was just cookies and cream ice cream dyed blue. My shit was neon blue for 3 days after that. It looked like legitimate play-doh. I was terrified. My roommate thought it was awesome….


thagthebarbarian

That's actually very interesting, in my experience large amounts of blue food coloring gets digested and turns my shit vibrant green


Ghostley92

It makes your carp glow


red5tz

Not unlike what Burger King did for Halloween recently with their black bun burgers that turned an eater's poop green. https://www.cbsnews.com/news/black-burger-green-poop-why-halloween-whopper-has-odd-effect/


access153

Glowing sushi is about to be 2022’s second hottest trend, right behind the shark cartilage enema.


7htlTGRTdtatH7GLqFTR

shartilage


SmokeyGlucose

That’s a triple whammy there


bathrobehero

I usually hate witty word merges, but I make an exception. How can you not with a word including "shart".


The_Adventurist

You can already get glowing sushi if you go fishing around Fukushima


arjemon

You can already get a shark cartilage enema if you’re not a pussy


WHEN_THE_ACID_KICKS

You leave my cat out of this


yes_him_Gary

This comment made me instantly miss Stefon. New York’s hottest foodie club is GLEWSH. Located in the we’re-not-republican-we-swear hot spot, Upper Eastside’s new eatery features raw fish that glow. Be sure to go tonight and test that well known adage, *What glows in must glow out*.


Iggyhopper

You want the hottest night club in town? We know it. Its got glowing fish Waterfalls made of purple Dancing squids All this can be found on the corner of 5th and main next to old man sushi and his pet coral reef


kidra31r

Nah man, that's the ocean spirit. Who let Zhao near the moon spirit again?


Bengineer97

PUT THOSE BACK IN THE SPIRIT OASIS WHERE YOU FOUND THEM OR SO HELP ME


pixeldust6

(So help me!)


mohressesa

So help me


Parking_Strength_932

...and CUT!


REpassword

“It’s a musical!”


diogenessexychicken

Ive never been more afraid of Iroh than that scene. "What ever you do to that spirit I will unleash on you tenfold!"


malicioustoast64

Iroh was on his chaotic-good shit in that scene and I absolutely loved it. Might just be one of my favorite scenes in the show.


levalore32

r/unexpectedavatar


ImaNukeYourFace

Nah I came looking for this comment, it is very expected avatar lol


ams1479

Thank you!


niktkolwiek

Holy crap!


A-Dolahans-hat

Holy carp!


Yurrrr__Brooklyn347

Glowy crap


Difficult-Fiance996

I hope not


fjordans

!prac yloH


Mediocre-Werewolf-79

Crapy hole


Comfortable_View5174

Does it mean soon we will have glowing crappy humans?? Asking for a friend


OddlyNotHandSoap

Does anyone know who exactly conducted this experiment? I wanna know more about who make this video.


MaximumNight860

I looked this up for that exact reason and found nothing posted outside of social media. I suspect this is fake. Also, the fact they used a soup bowl to hold the fish…😕


NightHawk521

This looks like CGI (or heavily filtered/edited) to me. Not to say this isn't possible (and it's been a while since I looked at this/was shown this in class), but IIRC they usually don't look like this to the naked eye with just a blacklight.


MaximumNight860

It’s very troubling that people are just believing this and not even questioning.


OddlyNotHandSoap

That’s what I was scared of considering they looks so pretty and I’ve seen glow fish before and compared to this they look like off brand great value


MJMurcott

Bioluminescence uses oxidative enzymes called luciferase to create a chemical reaction which produces light. Species can use bioluminescence to hide, lure prey or find a mate in the darkness and is so efficient that engineers are considering if there are any practical applications of the process. - https://youtu.be/XQSr0ShYPio


hlaforlife

I think this is fluorescence, there is a what quests to be a black light and florescent proteins like GFP come from jelly fish I believe.


GaseousGiant

This. Luciferase transgenics would need the substrate injected to produce light. These just glow under UV, as would jellyfish close to the surface.


R6_CollegeWiFi

Bioflourescence versus bioluminescence. Some animals are both.


leytorip7

Some animals are neither


GreyPilgrim1973

Like the lowly toad, or my friend, Larry


Lothium

Suck it Larry.


Thebraintickler

Negative, luciferase is used in fireflies, it requires ATP to produce light. this is a derivative of GFP, it uses a fluroflore inside of a protein and absorbs UV light and emits at a lower wavelength. The natural Green fluorescent protein has derivatives of Yellow, Red and Blue, subsequently known as YFP, RFP and BFP. They actually market these things in stores called "GLO fish". It was very weird because I worked a side job after grad school (where I used GFP and YFP to tag things occasionally) where I worked with tropical reef fish, and I came across these at a WalMart and was just like "wtf have they done...". I knew instantly that someone had just gotten these fish to express various GFP derivatives on their scales to do it, I just was interested/impressed in how they maintained the expression in animals with that kind of consistency. I was mainly tagging genes in E. coli or Arabidopsis (plant) and would use a standard antibiotic resistant plasmid control to keep expression, so I was convinced they had like a specialized diet, like how they used Lysine in Jurrassic Park. But nope. Still don't know how they did it. I've never worked with animals on a molecular level so a lot of that is just witchcraft to me, but I can grow high yield GFP in E. coli pretty well. I used to take it home and put it in my moms freezer to freak her out (I would purify it through FPLC, I had a PolyA tail added so it was quick, in case anyone was curious). Like, all of my work with fluorescent proteins was straight up Jurassic Park shit, I had no real reason to do it, I just wanted to. "I was so obsessed with the fact that I *could*, I never stopped to think if I *should*" was literally what was going on. I was cloning a lot of genes in E. coli for a while and I think I intended to use GPF as a positive control but ditched the concept early on for some reason, but still had the gene so I just grew liters of it a few times to purify, as just a way to kinda look busy, but also to make shit glow.


Dat_Redox

Instead of putting the gene on a plasmid or other piece of DNA that requires selection pressure to be replicated, they definitely just inserted it into the genome next to that of a protein expressed in the scales. That way since the protein is in the genome the fish will carry it without the need for selection pressure!


Thebraintickler

I figured it was something like this, I'm assuming they did with adenovirus? My biggest question is if the fish are fertile, and if the offspring carry the gene, or if it's something done to the eggs and you can't breed the GFP genes. Like, my biggest thing is with using bacteria and what little I've done with plants and tissue (immortal and primary) I can kinda go step by step on how to do this, but with a reproducing animal, not just dividing cells in media, I'm curious about it. I never tried to breed genetically altered arabidopsis, I was looking for peroxidase location in roots, which is like, really not what I do, it's just one of those things I got contracted out to do as a grad student. My work with primary cell lines is very similar, it was from an animal model and I kinda discovered I really don't like using animal models. Actually, the thing that really did it for me was I was doing TEM work and I was sharing space with a guy who was doing live organ dissection, and watching the heart beat and all that shit with the skin pinned to a board just made me nope the fuck out of it. I'm not even a squeemish person, like, I've killed plenty of animals in my spare time, hunting, rattle snakes, being a kid with a slingshot and BB gun, etc, so I didn't think it would bother me as much as it did. It's also kinda why I attempted to go as far away from medicine as I could. I ended up working in medicine, but I don't have to deal with patients at all, it's all data work, which is fine. But yeah, I kinda figured that's what they did, but I just don't know the actual technical steps to do it, so, like I said, it's basically witchcraft to me.


Burningshroom

They probably just used a restriction enzyme directly injected into an egg cell. This was a popular technique at the time the fish were originally produced and would guarantee inclusion of the gene in progenitor cells as the splice would be present in all the cells. It also means they only needed a single success as there is a single genome in an egg cell. With a few successful animals they could just selectively breed them to get homozygous progeny, which is easy because they fluoresce. This is why they were originally created. Attaching a gene to the GFP would give an easy indicator for successful transformations and progeny.


sni77

Poly his tag probably, not poly A tail


iambecomesoil

what


antoniohfernandes

So avatar biology world was better than ours after all.


AngusVanhookHinson

This would be the perfect ~~hobbyist~~ beginner fish. Small, easily taken care of, and unique in a way that makes a person want to be engaged. There's no way they would survive in the wild. They'd be eaten in minutes to hours. It's a completely human thing. Frankly, I see no downsides. Disclaimer: I am not a fish hobbyist


Sfumato-

Hobbyists can’t typically stand fish like this. Recreating natural environments is all the rage lately. So much so that mud bottoms and brown water are really popular


WamlytheCrabGod

Yep. Fully planted tanks are all the rage, not the least because they look phenomenal if done right. Not everyone's into blackwater though, it's good for fish but a lot of people like clear water better.


tehreal

Yes I do enjoy being able to see all of my fishies 🐠 🐠 👀


SpecterGT260

>mud bottoms and brown water are really popular I feel like this makes the hobby really approachable. Just fill a tank with muddy water and tell people there are fish in it


meowseehereboobs

It's an oversimplification. Dirted tanks are a thing, where instead of gravel or plain sand you use compost, soil etc, under a layer of sand. It provides good substrate and nutrition for plants. Black water tanks are tanks with added tannins, either from making a tea and adding it or from adding material that will naturally release tannins into the water as it breaks down. The water isn't black, just darker. Many fish do better in it, and it looks kinda cool.


AngusVanhookHinson

I think I should have been more clear. Beginners. I can totally get behind making the environment as close to nature as possible. But beginners, parents who got their kids a "my first fish kit", aren't going to want to spend the money for realistic environments. The kids may be enthusiastic for a short time, but unless you catch on fairly quickly, there's only so much that a few fish in a tank are going to do to keep you. Short attention spans and all that. But the whole glowing thing just may be enough to keep them interested for longer, and become that kind of enthusiastic hobbyist.


Spiked-bass4132

But carp need a pond


Kahnspiracy

Yeah, but what about "crap fish"?


Zappiticas

I think a lot of hobbiests dislike fish like this because they appeal to the type of people that generally aren’t willing to create a proper environment for a fish to thrive in. Such as children.


Spiked-bass4132

But carp need a pond


AngusVanhookHinson

Dude. Can you imagine a pond full of glowy fish? That's a great second step.


Spiked-bass4132

That would be amazing but it appears they need a certan light to glow but glowing carp are definatly not the best beginner fish not trying to be the killer of fun


AngusVanhookHinson

I appreciate that. Maybe another species?


Spiked-bass4132

Kinda already done to smaller fish https://www.glofish.com


Zappiticas

To add to this, specifically the Glo danios are great for beginners. All of the other glofish still require a decently large tank, about 40 gallon minimum for the tetras and rainbow sharks. But the danios can be kept in a 10 gallon.


PotentJelly13

You say this from experience in the hobby? Or you know about carp? Genuinely asking cause I’ve been in the hobby for a long time and never seen carp sold like other hobby fish are; unless we’re talking about stocking a pond or something.


AngusVanhookHinson

I'm not a hobbyist. I know nothing about them. So while my idea is getting some traction, I fear I may have accidentally been talking out of my ass.


Sfumato-

Sorry if I came across as “WELL AKSHUALLY”. I was trying to convey that fish people are kind of crazy and picky, but I may have put myself in that category :)


PotentJelly13

I appreciate the admission. Carp can get pretty big compared to majority of the tropical fish you’d see in this hobby. They usually are only kept in ponds, lakes or extremely large fish tanks. This would be dead within months of a true beginner owning it.


seanwd11

Carp are crap so I will allow this title to stay as is.


Tysenberg3204

Those would make great fishing bait


kuruttowo

*Sheldon Cooper joined the chat*


Millerpainkiller

Came here for this


ladyjanea

Also came here for this


emdafem

“So then I thought, ‘hey, loom’.”


IncreaseAfraid2454

Really cool! Can I get the source to this? I want to learn more! By the way, don't wanna be this guy, but you misspelled "carp".


Jayer244

If you want some infos on the method, those are called "Transgene organisms". A "transgene" is a gene is from another organism than the one where it is expressed in. In this case the gene cluster for bioluminescence was transfered from a jellyfish to a carp and expressed there. You can do really cool stuff with transgenes and they're one of the main methods in genetic sciences today to gather knowledge about the function of the gene and how it is regulated or expressed. In fruit flies for example they've been used to make them grow legs out of the place where their eyes are and have eyes grow on their legs. Really interesting shit.


billythesid

Transferring bioluminescence also creates a really obvious indicator of success for testing newly developed gene transfer methods.


SlothOfDoom

Don't wanna be this guy bit "crap fish" is a term for crappies. https://en.m.wikipedia.org/wiki/Crappie


Dramatic-Ad-6893

Yeah, those aren't crappie though.


FreeJokeMan

High quality crapfish


Dramatic-Ad-6893

Only the best crap for my friends!


jamminblue

Those are carp not crappies


hickgorilla

Glowing crap in water. Cool.


srv50

I’m guessing they’d like to stop being called crap fish now that they’ve been upgraded.


Maximum-Ad6907

Crap fish!


rodzi11a

Something fishy going on here...